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Sector: Healthcare
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Vertex Pharmaceuticals Incorpor

VRTX Large Cap

Healthcare · Biotechnology

Updated: Jun 14, 2026, 22:19 UTC

$444.93
-0.03% today
52W: $362.50 – $507.92
52W Low: $362.50 Position: 56.7% 52W High: $507.92

Price Chart

Key Metrics

P/E Ratio
26.39x
Price-to-Earnings
Forward P/E
20.72x
Forward Price/Earnings
P/S Ratio
9.24x
Price-to-Sales
EV/EBITDA
21.61x
Enterprise Value/EBITDA
Div. Yield
Annual dividend yield
Market Cap
$112.9B
Market Capitalization
Revenue Growth
7.8%
YoY Revenue Growth
Profit Margin
35.51%
Net profit margin
ROE
24.2%
Return on Equity
Beta
0.31
Market sensitivity
Short Interest
2%
% of float sold short
Avg. Volume
1,254,707
Average daily volume

Valuation Analysis

Signal
Fair
vs. S&P 500 avg P/E (24.7x)
Analyst Consensus
Buy
29 analysts
Avg. Price Target
$548.69
+23.32% upside
Target Range
$330.00 – $641.00

About the Company

Vertex Pharmaceuticals Incorporated operates as a biotechnology company in the United States, Europe, and internationally. The company offers transformative medicines for people with serious diseases with a focus on specialty markets, such as cystic fibrosis (CF), sickle cell disease (SCD), transfusion dependent beta thalassemia (TDT), and acute pain. It markets TRIKAFTA/KAFTRIO for people with CF with at least one F508del mutation for 2 years of age and older; ALYFTREK for the treatment for people with CF 6 years of age and older; SYMDEKO/SYMKEVI for treatment of patients with CF 6 years of age and older; ORKAMBI for CF patients 1 year or older; and KALYDECO for the treatment of patients with 1 month or older who have CF with ivacaftor. The company also develops CASGEVY for the treatment

Sector: Healthcare Industry: Biotechnology Country: United States Employees: 6,400 Exchange: NMS

Vertex Pharmaceuticals Incorpor Stock at a Glance

Vertex Pharmaceuticals Incorpor (VRTX) is currently trading at $444.93 with a market capitalization of $112.9B. The trailing P/E ratio stands at 26.39x, with a forward P/E of 20.72x. The 52-week range spans from $362.50 to $507.92; the current price is 12.4% below the yearly high. Year-over-year revenue growth stands at +7.8%. The net profit margin stands at 35.51%.

💰 Dividend

Vertex Pharmaceuticals Incorpor currently does not pay a dividend. The company typically reinvests its earnings into growth initiatives and product development.

📊 Analyst Rating

29 analysts rate Vertex Pharmaceuticals Incorpor (VRTX) on consensus: Buy. The average price target is $548.69, implying +23.32% from the current price. Analyst price targets range from $330.00 to $641.00.

Vertex Pharmaceuticals Incorpor: The Investment Case in Detail

Vertex Pharmaceuticals Incorpor (VRTX) operates in the Healthcare — specifically Biotechnology — and is headquartered in United States. Below is a structured read of the investment case built directly from the latest fundamentals, valuation multiples, analyst positioning and smart-money flows. Each section translates raw numbers into the investment logic they imply, so you can decide whether the risk/reward fits your portfolio.

The Bull Case

Earnings growth of 61.4% is outpacing revenue, a sign of operational leverage — fixed costs are being absorbed across a larger base. The combination of a 54.39% gross margin and 38.13% operating margin shows the business converts revenue into profit efficiently — a hallmark of competitive moat. Free cash flow is positive and net margins stand at 35.51%, meaning reported earnings translate into real cash that can fund buybacks, dividends or strategic acquisitions.

What to Watch Next

  • The forward P/E of 20.72x is meaningfully below the trailing 26.39x — analysts expect earnings to step up; the next earnings release is the test.
  • The analyst consensus price target implies 23.32% upside — if the next two quarters confirm the underlying thesis, target hikes typically follow.

Investment Thesis: Strengths & Weaknesses

Strengths
  • Profitable with 35.51% net margin
  • High return on equity (24.2% ROE)
  • High gross margin of 54.39% — indicates pricing power
  • Analyst consensus: Buy
  • Solid balance sheet with low debt (D/E 10.26)
  • Positive free cash flow
Weaknesses

No significant red flags in current metrics.

Technical Snapshot

50-Day MA
$436.75
+1.87% vs. price
200-Day MA
$438.43
+1.48% vs. price
Below 52W High
−12.4%
$507.92
Above 52W Low
+22.7%
$362.50

The price is in a transition zone relative to the moving averages — no clear signal.

Risk Profile

Market Risk (Beta)
0.31 · Defensive
Moves less than the overall market
Short Interest
2% · Low
% of float sold short
Debt-to-Equity
10.26 · Low
Total debt / equity

The data points to relatively defensive market behavior.

Trading Data

50-Day MA: $436.75
200-Day MA: $438.43
Volume: 924,189
Avg. Volume: 1,254,707
Short Ratio: 3.46
P/B Ratio: 5.84x
Debt/Equity: 10.26x
Free Cash Flow: $2.8B

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