State Street SPDR S&P Biotech ETF
XBI SectorUpdated: May 20, 2026, 21:17 UTC
Key Metrics
Top 10 Holdings
| Holding | Ticker | Weight | Bar |
|---|---|---|---|
| Apellis Pharmaceuticals Inc | APLS | 1.87% | |
| Revolution Medicines Inc Ordinary Shares | RVMD | 1.65% | |
| Travere Therapeutics Inc Ordinary Shares | TVTX | 1.62% | |
| Arrowhead Pharmaceuticals Inc | ARWR | 1.44% | |
| Twist Bioscience Corp | TWST | 1.42% | |
| Summit Therapeutics Inc Ordinary Shares | SMMT | 1.4% | |
| Alkermes PLC | ALKS | 1.38% | |
| TG Therapeutics Inc | TGTX | 1.37% | |
| Madrigal Pharmaceuticals Inc | MDGL | 1.36% | |
| Beam Therapeutics Inc | BEAM | 1.32% |
Sector Allocation
About This ETF
The State Street SPDR S&P Biotech ETF (XBI) is a Sector ETF with an expense ratio (TER) of 0.35% and $8.3B in assets under management., with its largest holdings being Apellis Pharmaceuticals Inc, Revolution Medicines Inc Ordinary Shares, Travere Therapeutics Inc Ordinary Shares. The ETF currently yields 0.34% in dividends. Year-to-date, XBI has returned +8.39%.
In seeking to track the performance of the S&P Biotechnology Select Industry Index (the "index"), the fund employs a sampling strategy. It generally invests substantially all, but at least 80%, of its total assets in the securities comprising the index. The index represents the biotechnology segment of the S&P Total Market Index ("S&P TMI").
FAQ — XBI
What is the TER of XBI (State Street SPDR S&P Biotech ETF)?
XBI has a Total Expense Ratio (TER) of 0.35 % per year. That sits above the sector category median (0.08 % across 13 peer ETFs). The TER is deducted directly from the fund and lowers your effective return.
What return has XBI delivered?
Performance for XBI: YTD: +8.39 % · 3-year p.a.: +14.29 % · 5-year p.a.: +0.40 %. Over 5 years, XBI underperforms the sector category median of +8.43 % by -8.03 pp. Past performance is no guarantee of future returns.
What are the top holdings of XBI?
The five largest positions in XBI are: APLS, RVMD, TVTX, ARWR, TWST. The full holdings list is updated daily on this page.
Does XBI pay dividends?
XBI has a current dividend yield of 0.34 %. Distributing ETFs pay this out in cash; accumulating versions reinvest it inside the fund. Check the share class on your broker before buying.
Where can I buy or set up a savings plan for XBI?
XBI is available at most major brokers. For a free monthly savings plan from €1, look at Trade Republic, Scalable Capital or Flatex. The broker comparison on this site shows fees, free-savings-plan ETFs and execution exchanges side by side.
Where can I buy XBI?
Compare the best brokers for ETF savings plans — low fees, trusted providers, fully regulated.